C22orf23

Across TCGA patient cohorts, C22orf23 mutation is significantly associated with the RNA expression of many other genes, with 339 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf23-associated genes across cancer lineages are RNA5SP19, MED28P4, and CRYGA. Each is linked with C22orf23 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf23-to-partner and partner-to-C22orf23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP19 grouped by C22orf23-low versus C22orf23-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf23→partner) and Y-score (partner→C22orf23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNA5SP19 →	+1.037	+5.039	<.001	.008	3	2
READ	MED28P4 →	+0.500	+5.039	<.001	.008	3	2
SKCM	CRYGA →	+0.092	+3.458	<.001	.003	3	2
SKCM	CAPZA1P3 →	+0.052	+3.211	<.001	.005	3	2
SKCM	R3HDM2P2 →	+0.030	+4.278	.001	<.001	3	2
SKCM	NPM1P38 →	+0.107	+3.770	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 339 associations by consensus.

RNA5SP19 by C22orf23 expression — READ

Explore this box plot interactively →