C22orf23

Across TCGA pan-cancer cohorts, C22orf23 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of C22orf23’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where C22orf23 RNA is repressed in tumor relative to normal tissue. In most cancer types C22orf23 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and LIHC are the cancer types where C22orf23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C22orf23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−1.000	.001	11	view →
THCA	All	II,III,IV	−0.694	<.001	9	view →
LIHC	Female	II,III,IV	+0.538	<.001	9	view →
UCEC	All	All	−1.546	<.001	8	view →
BRCA	All	III,IV	−1.119	<.001	6	view →
LUAD	Male	II,III,IV	−0.771	<.001	6	view →
STAD	Female	All	−1.201	.001	5	view →
HNSC	All	All	+0.449	.002	5	view →
COAD	All	II,III,IV	−0.417	.004	4	view →
CHOL	Male	All	+1.791	<.001	3	view →
ESCA	All	All	−1.349	.009	2	view →
PRAD	All	All	−0.796	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

C22orf23–BLCA

Open the BLCA breakdown →