C22orf15

Across TCGA patient cohorts, C22orf15 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C22orf15-associated genes across cancer lineages are TRGJP2, TCERG1L-AS1, and COX6CP11. Each is linked with C22orf15 in more than 1 cancer types. Because this analysis shows association rather than direction, both C22orf15-to-partner and partner-to-C22orf15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by C22orf15-low versus C22orf15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C22orf15→partner) and Y-score (partner→C22orf15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRGJP2 →	+0.920	+2.888	<.001	.003	3	2
UCEC	TCERG1L-AS1 →	+0.457	+2.496	<.001	.007	3	2
UCEC	COX6CP11 →	+0.230	+3.835	<.001	<.001	3	2
UCEC	CCDC92B →	+0.415	+2.752	<.001	.003	3	2
COAD	RNU6-1 →	+0.645	+3.951	.006	.003	3	1
COAD	MIR572 →	+0.354	+4.917	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

TRGJP2 by C22orf15 expression — UCEC

Explore this box plot interactively →