C21orf91

Across TCGA pan-cancer cohorts, C21orf91 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated C21orf91 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher C21orf91 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C21orf91 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM and UCEC are the cancer types where C21orf91 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	1.000	0.628	.013	24	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

C21orf91–THYM (OS)

Open the THYM breakdown →