C21orf58

Across TCGA patient cohorts, C21orf58 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C21orf58-associated genes across cancer lineages are PNMA6E, MIR1266, and PABPC1L2B-AS1. Each is linked with C21orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C21orf58-to-partner and partner-to-C21orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNMA6E grouped by C21orf58-low versus C21orf58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C21orf58→partner) and Y-score (partner→C21orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PNMA6E →	+0.736	+3.378	.001	.008	3	2
UCEC	MIR1266 →	+0.287	+4.186	<.001	<.001	3	2
UCEC	PABPC1L2B-AS1 →	+0.014	+4.245	<.001	.006	3	2
UCEC	RNU6-362P →	+0.145	+5.060	<.001	.001	3	2
LIHC	RNU7-4P →	+0.579	+5.355	<.001	.005	3	1
LIHC	FKBP1AP2 →	+0.179	+6.149	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

PNMA6E by C21orf58 expression — UCEC

Explore this box plot interactively →