C20orf27

Across TCGA pan-cancer cohorts, C20orf27 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C20orf27 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher C20orf27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C20orf27 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where C20orf27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.467	0.946	.002	44	view →
PDAC	OS	Quartile	II,III,IV	0.718	0.367	.014	26	view →
CCRCC	OS	Median	III,IV	0.644	0.968	.001	20	view →
LUAD	OS	Tertile	III,IV	0.254	0.869	.003	12	view →
LSCC	DFS	Median	II,III,IV	0.816	0.548	.021	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C20orf27–UCEC (DFS)

Open the UCEC breakdown →