C20orf27

Across TCGA pan-cancer cohorts, C20orf27 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of C20orf27’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C20orf27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C20orf27 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where C20orf27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C20orf27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.499	<.001	12	view →
KIRC	Male	IV	+0.943	<.001	12	view →
COAD	Female	All	+1.685	<.001	11	view →
LIHC	Female	II,III,IV	+1.440	<.001	9	view →
KIRP	All	II,III,IV	+1.046	<.001	9	view →
LUSC	Male	II,III,IV	+0.980	<.001	6	view →
THCA	All	II,III,IV	+0.351	.005	4	view →
CHOL	Male	All	+2.200	<.001	3	view →
KICH	Female	All	−0.884	<.001	3	view →
READ	Male	All	+1.203	.015	2	view →
BLCA	Male	III,IV	−0.627	.025	2	view →
UCEC	All	All	−0.539	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

C20orf27–HNSC

Open the HNSC breakdown →