C20orf27

Across TCGA patient cohorts, C20orf27 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C20orf27-associated genes across cancer lineages are Ku80, MEK1, and Notch1. Each is linked with C20orf27 in more than 1 cancer types. Because this analysis shows association rather than direction, both C20orf27-to-partner and partner-to-C20orf27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by C20orf27-low versus C20orf27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C20orf27→partner) and Y-score (partner→C20orf27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.368	+3.335	.002	.005	3	1
UCEC	MEK1 →	+0.450	+3.000	.018	.036	3	1
UCEC	Notch1 →	+0.208	+2.820	.004	.035	3	1
UCEC	Syk →	+0.451	+2.183	.021	.035	3	1
UCEC	VHL →	-1.149	-3.321	.001	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.712	+3.019	.022	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ku80 by C20orf27 expression — UCEC

Explore this box plot interactively →