C20orf27

Across TCGA cell cohorts, C20orf27 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,190 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible C20orf27-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Positive regulation of protein localization to endoplasmic reticulum, and Enzyme-directed rRNA pseudouridine synthesis. Each is linked with C20orf27 in more than 15 cancer types. Because this analysis shows association rather than direction, both C20orf27-to-partner and partner-to-C20orf27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by C20orf27-low versus C20orf27-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C20orf27→partner) and Y-score (partner→C20orf27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	rRNA pseudouridine synthesis →	+0.117	+0.736	<.001	<.001	3	16
OVARY	Positive regulation of protein localization to endoplasmic reticulum →	+0.103	+1.004	<.001	<.001	3	15
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	+0.139	+0.890	<.001	<.001	3	15
URINARY_TRACT	Termination of RNA polymerase III transcription →	+0.141	+1.607	<.001	<.001	3	14
BONE	Maturation of 5.8S rRNA →	+0.182	+1.191	<.001	<.001	3	14
BONE	rRNA transcription →	+0.117	+0.747	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,190 associations by consensus.

rRNA pseudouridine synthesis by C20orf27 expression — LUNG_SCLC

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