C20orf197

Across TCGA pan-cancer cohorts, C20orf197 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C20orf197’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C20orf197 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C20orf197 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where C20orf197 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C20orf197 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.439	<.001	12	view →
HNSC	All	All	+0.592	<.001	10	view →
THCA	All	All	+0.180	.001	8	view →
KIRP	All	All	+0.194	<.001	7	view →
LUAD	Female	All	+0.901	<.001	6	view →
BRCA	All	All	−0.103	.016	4	view →
LUSC	All	All	+0.407	.005	2	view →
BLCA	All	All	+0.396	.049	2	view →
CHOL	All	All	+0.210	.003	2	view →
UCEC	All	All	−0.197	.007	2	view →
READ	Female	All	−0.128	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

C20orf197–KIRC

Open the KIRC breakdown →