C20orf181

Across TCGA pan-cancer cohorts, C20orf181 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated C20orf181 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher C20orf181 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C20orf181 expression acts as an unfavorable survival marker, although some lineages such as BLCA and MESO show a favorable association.

TGCT, BLCA, and LUAD are the cancer types where C20orf181 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Tertile	III,IV	0.003	1.000	<.001	72	view →
BLCA	DFS	Tertile	III,IV	0.506	0.211	<.001	45	view →
LUAD	DFS	Tertile	IV	0.339	0.742	.004	36	view →
COAD	DFS	Tertile	III,IV	0.206	0.709	.001	36	view →
GBM	OS	Tertile	All	0.210	0.430	<.001	36	view →
OV	OS	Quartile	IV	0.531	0.864	.003	34	view →
MESO	OS	Tertile	III,IV	1.000	0.381	.017	27	view →
LIHC	OS	Tertile	II,III,IV	0.135	0.621	.004	27	view →
LAML	DFS	Quartile	All	0.185	0.523	.006	24	view →
LGG	DFS	Tertile	All	0.856	0.360	.002	18	view →
SKCM	OS	Tertile	II,III,IV	0.768	0.307	.031	9	view →
STAD	OS	Tertile	IV	0.111	0.433	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

C20orf181–TGCT (OS)

Open the TGCT breakdown →