C2-AS1

Across TCGA pan-cancer cohorts, C2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C2-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C2-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, KIRC, and UVM are the cancer types where C2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.762	0.577	<.001	125	view →
KIRC	OS	Tertile	All	0.545	0.703	<.001	108	view →
UVM	DFS	Tertile	II,III,IV	0.307	0.825	<.001	101	view →
SKCM	OS	Tertile	All	0.424	0.286	<.001	90	view →
BLCA	OS	Quartile	All	0.548	0.316	.001	64	view →
ACC	DFS	Tertile	III,IV	0.071	0.417	.005	48	view →
LGG	DFS	Median	All	0.303	0.482	<.001	43	view →
UCEC	DFS	Median	All	0.539	0.733	<.001	36	view →
READ	OS	Tertile	All	1.000	0.752	.003	31	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	20	view →
PCPG	DFS	Quartile	All	0.753	0.928	.009	13	view →
TGCT	DFS	Tertile	All	0.957	0.769	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C2-AS1–HNSC (OS)

Open the HNSC breakdown →