C2-AS1

Across TCGA pan-cancer cohorts, C2-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of C2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C2-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where C2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.317	<.001	11	view →
COAD	Female	II,III,IV	+0.715	<.001	10	view →
LUAD	Female	II,III,IV	−0.730	<.001	8	view →
HNSC	All	All	+0.309	.001	6	view →
STAD	All	All	+0.263	.002	6	view →
LUSC	All	All	−0.547	<.001	5	view →
READ	All	All	+0.628	.003	4	view →
BRCA	All	II,III,IV	+0.193	<.001	4	view →
KIRP	Male	All	+0.137	.003	4	view →
LIHC	Male	All	+0.445	.003	2	view →
PRAD	All	All	+0.271	<.001	2	view →
THCA	Male	II,III,IV	+0.069	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

C2-AS1–KIRC

Open the KIRC breakdown →