C1orf74

Across TCGA patient cohorts, C1orf74 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,887 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible C1orf74-associated proteins across cancer lineages are IRF6, IPO9, and PRRC2C. Each is linked with C1orf74 in more than 6 cancer types. Because this analysis shows association rather than direction, both C1orf74-to-partner and partner-to-C1orf74 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C1orf74 versus IRF6 in PDAC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf74→partner) and Y-score (partner→C1orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IRF6 →	+0.593	+0.456	<.001	<.001	3	7
LUAD	IPO9 →	+0.369	+0.551	<.001	<.001	3	5
LSCC	PRRC2C →	+0.171	+0.536	<.001	<.001	3	4
HNSC	RTKN →	+0.320	+0.636	<.001	<.001	3	4
UCEC	IRF2BP2 →	+0.264	+0.617	<.001	<.001	3	4
PDAC	NECTIN4 →	+0.460	+0.415	.005	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,887 associations by consensus.

C1orf74 vs IRF6 — PDAC

Explore this scatter interactively →