C1orf74

Across TCGA patient cohorts, C1orf74 mutation is significantly associated with the RNA expression of many other genes, with 958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf74-associated genes across cancer lineages are RNU4-58P, RNU6-36P, and RNU6-13P. Each is linked with C1orf74 in more than 2 cancer types. Because this analysis shows association rather than direction, both C1orf74-to-partner and partner-to-C1orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by C1orf74-low versus C1orf74-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf74→partner) and Y-score (partner→C1orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU4-58P →	+0.477	+6.734	<.001	<.001	3	3
COAD	RNU6-36P →	+1.435	+4.295	<.001	.008	3	2
COAD	RNU6-13P →	+0.830	+4.893	<.001	.005	3	2
COAD	SNORD56B →	+2.358	+4.693	<.001	.007	3	2
COAD	SNORD65C →	+2.643	+4.693	<.001	.007	3	2
COAD	RN7SKP261 →	+0.353	+5.484	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 958 associations by consensus.

RNU4-58P by C1orf74 expression — COAD

Explore this box plot interactively →