Across TCGA pan-cancer cohorts, C1orf68 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C1orf68’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where C1orf68 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C1orf68 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

LUSC, HNSC, and PRAD are the cancer types where C1orf68 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf68 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.766	<.001	6	view →
HNSC	Male	IV	+0.708	.024	2	view →
PRAD	All	All	−0.020	.026	2	view →
THCA	All	All	+0.008	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: C1orf68 RNA expression & survival · all C1orf68 data types