C1orf50

Across TCGA pan-cancer cohorts, C1orf50 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C1orf50 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C1orf50 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1orf50 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where C1orf50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.887	0.198	.024	12	view →
LUAD	DFS	Quartile	All	0.494	0.823	.006	7	view →
HNSC	DFS	Tertile	III,IV	1.000	0.901	.022	6	view →
OV	DFS	Median	All	0.870	1.000	.038	4	view →
LSCC	DFS	Quartile	II,III,IV	0.993	0.699	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C1orf50–CCRCC (DFS)

Open the CCRCC breakdown →