C1orf50

Across TCGA patient cohorts, C1orf50 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf50-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and PKC-b-II_pS660. Each is linked with C1orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf50-to-partner and partner-to-C1orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by C1orf50-low versus C1orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf50→partner) and Y-score (partner→C1orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.701	-2.986	.006	.037	3	1
UCEC	PDCD4 →	-0.670	-3.000	.013	.037	3	1
UCEC	PKC-b-II_pS660 →	-0.382	-3.000	.016	.037	3	1
UCEC	Notch1 →	+0.236	+3.000	.003	.037	1	1
UCEC	p27_pT198 →	+0.123	+3.000	.046	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p38-MAPK_pT180_Y182 by C1orf50 expression — UCEC

Explore this box plot interactively →