C1orf50

Across TCGA cell cohorts, C1orf50 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible C1orf50-associated genes across cancer lineages are XAGE3 and PADI6. Each is linked with C1orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf50-to-partner and partner-to-C1orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE3 grouped by C1orf50-low versus C1orf50-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf50→partner) and Y-score (partner→C1orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	XAGE3 →	+0.128	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	PADI6 →	+0.051	+3.866	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

XAGE3 by C1orf50 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →