C1orf50

Across TCGA cell cohorts, C1orf50 mutation is significantly associated with the mutation status of many other genes, with 947 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1orf50-associated genes across cancer lineages are STRIP2, SPOCD1, and MYO1F. Each is linked with C1orf50 in more than 2 cancer types. Because this analysis shows association rather than direction, both C1orf50-to-partner and partner-to-C1orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STRIP2 grouped by C1orf50-low versus C1orf50-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf50→partner) and Y-score (partner→C1orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	STRIP2 →	+4.239	+5.053	.007	.007	1	3
LUNG_NSCLC_LUAD	SPOCD1 →	+3.000	+3.662	.007	.007	1	3
LUNG_NSCLC_LUAD	MYO1F →	+5.000	+4.187	.008	.008	1	3
LUNG_NSCLC_LUAD	BMP10 →	+4.000	+4.303	.001	.001	1	3
LARGE_INTESTINE	C12orf50 →	+2.865	+4.217	.007	.007	1	3
LARGE_INTESTINE	LINGO1 →	+3.087	+4.392	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 947 associations by consensus.

STRIP2 by C1orf50 expression — SKIN

Explore this box plot interactively →