C1orf35

Across TCGA pan-cancer cohorts, C1orf35 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated C1orf35 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher C1orf35 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1orf35 expression acts as an unfavorable survival marker, although some lineages such as OV and SKCM show a favorable association.

KIRC, ACC, and KIRP are the cancer types where C1orf35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.552	0.740	<.001	134	view →
ACC	DFS	Median	All	0.169	0.772	<.001	117	view →
KIRP	DFS	Median	All	0.779	0.923	<.001	112	view →
LIHC	OS	Median	All	0.588	0.809	<.001	60	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	41	view →
UVM	DFS	Median	All	0.276	0.642	.012	35	view →
COAD	OS	Quartile	All	0.687	0.872	.011	32	view →
READ	OS	Median	III,IV	0.325	0.827	.008	31	view →
UCS	DFS	Tertile	IV	0.239	0.890	.010	30	view →
OV	OS	Quartile	III,IV	0.727	0.597	.009	26	view →
PRAD	DFS	Tertile	All	0.718	0.910	<.001	18	view →
SKCM	DFS	Median	III,IV	0.588	0.388	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

C1orf35–KIRC (DFS)

Open the KIRC breakdown →