C1orf35

Across TCGA pan-cancer cohorts, C1orf35 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of C1orf35’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C1orf35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C1orf35 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where C1orf35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.650	<.001	12	view →
COAD	Male	IV	+1.303	<.001	11	view →
BLCA	Female	III,IV	+1.182	<.001	10	view →
HNSC	Male	IV	+1.150	<.001	10	view →
KIRP	All	III,IV	+0.909	<.001	10	view →
LIHC	Male	II,III,IV	+1.833	<.001	9	view →
STAD	Male	II,III,IV	+0.869	<.001	9	view →
LUSC	All	II,III,IV	+1.056	<.001	8	view →
LUAD	All	III,IV	+0.660	<.001	8	view →
BRCA	All	III,IV	+0.888	<.001	6	view →
KICH	Female	All	−0.878	<.001	6	view →
CHOL	Male	All	+2.658	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

C1orf35–KIRC

Open the KIRC breakdown →