C1orf35

Across TCGA pan-cancer cohorts, C1orf35 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C1orf35 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C1orf35 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C1orf35 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where C1orf35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.888	1.000	.003	29	view →
PDAC	DFS	Median	III,IV	0.964	0.466	.007	9	view →
HNSC	OS	Quartile	III,IV	0.816	1.000	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C1orf35–CCRCC (OS)

Open the CCRCC breakdown →