C1orf35

Across TCGA pan-cancer cohorts, C1orf35 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of C1orf35’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C1orf35 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C1orf35 is over-expressed in tumor.

COAD, LUAD, and LSCC are the cancer types where C1orf35 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf35 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.534	<.001	10	view →
LUAD	Female	III,IV	+0.947	<.001	9	view →
LSCC	Male	II,III,IV	+0.932	<.001	9	view →
CCRCC	Male	III,IV	+0.342	<.001	9	view →
HNSC	Male	IV	+0.516	<.001	8	view →
PDAC	All	All	+0.264	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

C1orf35–COAD

Open the COAD breakdown →