C1orf226

Across TCGA patient cohorts, C1orf226 mutation is significantly associated with the RNA expression of many other genes, with 2,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf226-associated genes across cancer lineages are GAPDHP56, TAF11L14, and H3Y2. Each is linked with C1orf226 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf226-to-partner and partner-to-C1orf226 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDHP56 grouped by C1orf226-low versus C1orf226-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf226→partner) and Y-score (partner→C1orf226) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAPDHP56 →	+0.098	+7.108	<.001	<.001	3	2
LUAD	TAF11L14 →	+0.536	+5.157	<.001	.007	3	2
LUAD	H3Y2 →	+0.373	+4.990	.002	.009	3	2
LUAD	MIR6817 →	+0.442	+5.279	.001	.006	3	2
UCEC	H3Y1 →	+0.926	+2.394	<.001	<.001	3	2
CESC	RNU7-19P →	+0.808	+5.269	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,186 associations by consensus.

GAPDHP56 by C1orf226 expression — LUAD

Explore this box plot interactively →