C1orf216

Across TCGA patient cohorts, C1orf216 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf216-associated genes across cancer lineages are RNA5SP424, RNU6-1127P, and RNU6-577P. Each is linked with C1orf216 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf216-to-partner and partner-to-C1orf216 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP424 grouped by C1orf216-low versus C1orf216-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf216→partner) and Y-score (partner→C1orf216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP424 →	+0.599	+6.147	<.001	.002	3	2
SKCM	RNU6-1127P →	+0.297	+4.867	<.001	.005	3	2
SKCM	RNU6-577P →	+0.436	+4.381	.003	.006	3	1
SKCM	MIR3170 →	+0.661	+4.970	<.001	.005	3	1
BLCA	CRYGA →	+0.157	+5.497	<.001	.004	3	1
BLCA	OR8G2P →	+0.081	+5.411	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

RNA5SP424 by C1orf216 expression — BLCA

Explore this box plot interactively →