C1orf21

Across TCGA pan-cancer cohorts, C1orf21 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C1orf21 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher C1orf21 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated C1orf21 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where C1orf21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	1.000	0.380	.003	12	view →
PDAC	DFS	Median	III,IV	0.595	0.196	.009	9	view →
GBM	DFS	Quartile	All	0.900	0.592	.049	1	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C1orf21–LUAD (OS)

Open the LUAD breakdown →