C1orf21

Across TCGA pan-cancer cohorts, C1orf21 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C1orf21’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C1orf21 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C1orf21 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where C1orf21 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf21 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.961	<.001	9	view →
HNSC	All	III,IV	−0.318	<.001	8	view →
LUAD	All	All	−0.191	<.001	5	view →
LSCC	All	All	−0.186	.002	4	view →
OV	All	All	−1.294	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

C1orf21–COAD

Open the COAD breakdown →