C1orf189

Across TCGA patient cohorts, C1orf189 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf189-associated genes across cancer lineages are OR51M1, NMNAT1P3, and OR6M3P. Each is linked with C1orf189 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf189-to-partner and partner-to-C1orf189 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51M1 grouped by C1orf189-low versus C1orf189-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf189→partner) and Y-score (partner→C1orf189) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR51M1 →	+0.272	+5.122	<.001	.004	3	1
COAD	NMNAT1P3 →	+0.088	+4.893	.006	.005	3	1
COAD	OR6M3P →	+0.404	+4.693	<.001	.007	3	1
UCEC	MIR6801 →	+0.832	+3.543	<.001	.002	3	1
UCEC	MIR8070 →	+0.655	+3.132	.004	.007	3	1
LUAD	MTND4LP12 →	+0.069	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR51M1 by C1orf189 expression — COAD

Explore this box plot interactively →