C1orf189

Across TCGA pan-cancer cohorts, C1orf189 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C1orf189 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C1orf189 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C1orf189 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

ACC, MESO, and COAD are the cancer types where C1orf189 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	II,III,IV	0.249	0.803	<.001	89	view →
MESO	OS	Quartile	III,IV	0.569	0.276	.010	78	view →
COAD	DFS	Quartile	All	0.702	0.859	.008	30	view →
READ	DFS	Median	IV	0.379	0.760	.009	30	view →
KIRC	DFS	Median	III,IV	0.554	0.376	.005	26	view →
BRCA	OS	Tertile	IV	0.909	0.311	.002	25	view →
CESC	OS	Median	II,III,IV	0.768	0.413	.023	20	view →
UCEC	OS	Quartile	All	0.975	0.895	.001	20	view →
LGG	OS	Median	All	0.764	0.852	.004	20	view →
GBM	OS	Tertile	All	0.240	0.566	.004	17	view →
SKCM	DFS	Quartile	III,IV	0.745	0.543	.005	15	view →
UCS	OS	Tertile	IV	0.828	0.387	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C1orf189–ACC (OS)

Open the ACC breakdown →