Across TCGA patient cohorts, C1orf185 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf185-associated genes across cancer lineages are ACC_pS79, MEK1, and p27_pT157. Each is linked with C1orf185 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf185-to-partner and partner-to-C1orf185 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf185→partner) and Y-score (partner→C1orf185) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.362	+3.321	.046	.010	3	1
UCEC	MEK1 →	+0.451	+3.321	.018	.010	3	1
UCEC	p27_pT157 →	-0.066	-3.321	.029	.010	3	1
UCEC	P-Cadherin →	-0.202	-3.308	.007	.010	3	1
UCEC	PRAS40_pT246 →	+0.283	+2.183	.001	.035	3	1
UCEC	Rad50 →	-0.319	-3.321	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

C1orf185 survival (RNA) · tumor vs normal (RNA) · all C1orf185 data types