Across TCGA pan-cancer cohorts, C1orf185 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of C1orf185’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where C1orf185 RNA is repressed in tumor relative to normal tissue. In most cancer types C1orf185 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and KIRC are the cancer types where C1orf185 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf185 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.125	<.001	6	view →
KICH	Female	All	−0.050	.004	3	view →
KIRC	All	IV	+0.032	.018	3	view →
PRAD	All	All	+0.025	.027	2	view →
LUAD	All	All	+0.029	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: C1orf185 RNA expression & survival · all C1orf185 data types