C1orf158

Across TCGA patient cohorts, C1orf158 mutation is significantly associated with the RNA expression of many other genes, with 1,575 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf158-associated genes across cancer lineages are FRG1HP, CKS1BP5, and RNU6-782P. Each is linked with C1orf158 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf158-to-partner and partner-to-C1orf158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG1HP grouped by C1orf158-low versus C1orf158-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf158→partner) and Y-score (partner→C1orf158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FRG1HP →	+0.629	+3.491	.002	.002	3	2
HNSC	CKS1BP5 →	+0.167	+6.008	<.001	.002	3	2
HNSC	RNU6-782P →	+0.375	+5.368	<.001	.005	3	2
SKCM	RNA5SP461 →	+0.070	+4.495	<.001	.002	3	2
UCEC	RPL17 →	+0.565	+3.459	.007	.005	3	2
UCEC	MIR4445 →	+0.269	+5.156	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,575 associations by consensus.

FRG1HP by C1orf158 expression — UCEC

Explore this box plot interactively →