C1orf158

Across TCGA pan-cancer cohorts, C1orf158 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of C1orf158’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where C1orf158 RNA is repressed in tumor relative to normal tissue. In most cancer types C1orf158 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and THCA are the cancer types where C1orf158 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C1orf158 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.557	<.001	8	view →
LUAD	Female	All	−1.263	<.001	8	view →
THCA	Female	All	−0.697	<.001	7	view →
KIRC	Male	All	−0.027	<.001	6	view →
KICH	All	All	−0.026	.004	6	view →
BRCA	Female	All	+0.092	.006	4	view →
COAD	Female	II,III,IV	+0.010	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

C1orf158–LUSC

Open the LUSC breakdown →