C1orf158

Across TCGA patient cohorts, C1orf158 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf158-associated genes across cancer lineages are Ku80, mTOR_pS2448, and Myosin-IIa. Each is linked with C1orf158 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf158-to-partner and partner-to-C1orf158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by C1orf158-low versus C1orf158-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf158→partner) and Y-score (partner→C1orf158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.282	+3.335	.023	.005	3	1
UCEC	mTOR_pS2448 →	-0.173	-2.986	.026	.035	3	1
UCEC	Myosin-IIa →	+0.213	+2.177	.028	.035	3	1
UCEC	N-Cadherin →	+0.243	+2.817	.029	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.552	-3.000	.019	.036	3	1
UCEC	Paxillin →	+0.300	+2.817	.027	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Ku80 by C1orf158 expression — UCEC

Explore this box plot interactively →