C1orf127

Across TCGA patient cohorts, C1orf127 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf127-associated genes across cancer lineages are PDCD4, TIGAR, and ATM. Each is linked with C1orf127 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf127-to-partner and partner-to-C1orf127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by C1orf127-low versus C1orf127-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf127→partner) and Y-score (partner→C1orf127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.580	-3.169	.004	.018	3	2
UCEC	TIGAR →	+0.179	+2.142	.007	.010	3	2
UCEC	ATM →	-0.741	-3.308	<.001	.009	3	2
UCEC	MIG-6 →	+0.098	+2.128	.024	.010	3	1
UCEC	mTOR_pS2448 →	-0.202	-3.446	.001	.005	3	1
UCEC	mTOR →	-0.152	-2.115	.031	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PDCD4 by C1orf127 expression — UCEC

Explore this box plot interactively →