C1orf127

Across TCGA pan-cancer cohorts, C1orf127 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated C1orf127 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher C1orf127 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1orf127 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SARC show a favorable association.

BRCA, HNSC, and ACC are the cancer types where C1orf127 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	II,III,IV	0.831	0.929	<.001	79	view →
HNSC	DFS	Median	III,IV	0.432	0.225	.002	68	view →
ACC	OS	Median	III,IV	0.588	0.885	.001	36	view →
UVM	DFS	Median	All	0.352	0.591	.004	36	view →
LAML	DFS	Tertile	All	0.411	0.714	<.001	30	view →
SARC	OS	Tertile	All	0.867	0.672	<.001	26	view →
COAD	OS	Quartile	III,IV	0.299	0.781	.008	26	view →
LUAD	OS	Quartile	All	0.863	0.746	.003	25	view →
CHOL	OS	Tertile	All	0.778	0.388	.023	22	view →
KIRC	DFS	Median	IV	0.235	0.421	.017	20	view →
STAD	OS	Median	IV	0.728	0.160	.005	18	view →
LGG	OS	Tertile	All	0.824	0.914	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

C1orf127–BRCA (DFS)

Open the BRCA breakdown →