C1orf109

Across TCGA patient cohorts, C1orf109 mutation is significantly associated with the RNA expression of many other genes, with 647 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf109-associated genes across cancer lineages are MIR4694, AP1S3, and DDX19B. Each is linked with C1orf109 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf109-to-partner and partner-to-C1orf109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4694 grouped by C1orf109-low versus C1orf109-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf109→partner) and Y-score (partner→C1orf109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4694 →	+0.444	+4.351	<.001	.002	3	2
UCEC	AP1S3 →	+0.808	+3.513	<.001	.002	3	1
UCEC	DDX19B →	+0.480	+3.545	<.001	.002	3	1
UCEC	RNF166 →	+0.705	+3.332	<.001	.005	3	1
UCEC	RAPGEF6 →	+0.411	+3.337	.006	.005	3	1
UCEC	NAE1 →	+0.718	+3.370	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 647 associations by consensus.

MIR4694 by C1orf109 expression — SKCM

Explore this box plot interactively →