C1orf105

Across TCGA patient cohorts, C1orf105 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf105-associated genes across cancer lineages are RNU6-497P, RAP1BP1, and PANK4. Each is linked with C1orf105 in more than 2 cancer types. Because this analysis shows association rather than direction, both C1orf105-to-partner and partner-to-C1orf105 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-497P grouped by C1orf105-low versus C1orf105-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf105→partner) and Y-score (partner→C1orf105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-497P →	+0.347	+4.481	<.001	.009	3	3
SKCM	RAP1BP1 →	+0.149	+2.284	<.001	.004	3	2
UCEC	PANK4 →	+0.445	+2.711	.002	.003	3	2
UCEC	UBXN6 →	+0.466	+3.632	.001	.001	3	2
UCEC	SARS1 →	+0.428	+3.362	.009	.005	3	2
LUAD	LINC01318 →	+0.263	+4.631	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

RNU6-497P by C1orf105 expression — LUAD

Explore this box plot interactively →