C1orf105

Across TCGA pan-cancer cohorts, C1orf105 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C1orf105 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher C1orf105 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C1orf105 expression acts as an unfavorable survival marker, although some lineages such as ACC and UCS show a favorable association.

KIRP, ACC, and LUAD are the cancer types where C1orf105 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.324	0.754	<.001	89	view →
ACC	OS	Median	All	0.804	0.424	<.001	82	view →
LUAD	OS	Tertile	All	0.759	0.868	.004	66	view →
HNSC	OS	Median	All	0.610	0.759	<.001	61	view →
BRCA	DFS	Quartile	II,III,IV	0.897	0.967	<.001	57	view →
CESC	DFS	Tertile	All	0.408	0.637	.005	36	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	33	view →
UCS	DFS	Tertile	II,III,IV	0.543	0.143	.014	26	view →
UCEC	DFS	Median	All	0.537	0.754	.001	20	view →
GBM	DFS	Median	All	0.244	0.163	.010	18	view →
TGCT	DFS	Median	All	0.511	0.824	.001	18	view →
SARC	DFS	Tertile	All	0.450	0.668	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C1orf105–KIRP (OS)

Open the KIRP breakdown →