C1orf105

Across TCGA patient cohorts, C1orf105 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1orf105-associated genes across cancer lineages are Annexin-1, ERK2, and GAPDH. Each is linked with C1orf105 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1orf105-to-partner and partner-to-C1orf105 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by C1orf105-low versus C1orf105-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1orf105→partner) and Y-score (partner→C1orf105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.648	+2.459	.010	.020	3	2
UCEC	ERK2 →	+0.198	+2.999	.033	.035	3	1
UCEC	GAPDH →	+0.551	+3.000	.033	.036	3	1
UCEC	TIGAR →	+0.192	+2.486	.009	.011	3	1
UCEC	Tuberin →	+0.368	+2.331	.004	.019	3	1
UCEC	p62 Lck ligand →	+0.346	+3.009	.027	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Annexin-1 by C1orf105 expression — UCEC

Explore this box plot interactively →