C1S

Across TCGA pan-cancer cohorts, C1S mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C1S data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C1S mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1S expression acts as an unfavorable survival marker.

COAD, UCEC, and CCRCC are the cancer types where C1S mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.885	1.000	.019	36	view →
UCEC	DFS	Tertile	III,IV	0.366	1.000	.020	18	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	15	view →
GBM	DFS	Tertile	All	0.572	0.895	<.001	12	view →
LSCC	DFS	Median	All	0.384	0.875	.005	11	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C1S–COAD (DFS)

Open the COAD breakdown →