C1QBP

Across TCGA patient cohorts, C1QBP mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1QBP-associated genes across cancer lineages are Notch1, Tuberin, and Caspase-8. Each is linked with C1QBP in more than 1 cancer types. Because this analysis shows association rather than direction, both C1QBP-to-partner and partner-to-C1QBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by C1QBP-low versus C1QBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1QBP→partner) and Y-score (partner→C1QBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.183	+2.817	.018	.036	3	1
UCEC	Tuberin →	+0.369	+3.169	.012	.020	3	1
UCEC	Caspase-8 →	-0.286	-3.169	.038	.020	3	1
UCEC	p62 Lck ligand →	+0.501	+2.817	.005	.036	2	1
UCEC	PDK1 →	-0.145	-3.169	.014	.020	2	1
UCEC	Di-Ras3 →	-0.225	-3.169	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by C1QBP expression — UCEC

Explore this box plot interactively →