C1QBP

Across TCGA pan-cancer cohorts, C1QBP RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated C1QBP data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher C1QBP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1QBP expression acts as an unfavorable survival marker, although some lineages such as READ and BRCA show a favorable association.

UVM, LUAD, and LIHC are the cancer types where C1QBP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.290	0.755	.002	86	view →
LUAD	DFS	Median	II,III,IV	0.300	0.591	<.001	81	view →
LIHC	OS	Median	III,IV	0.524	0.761	.001	43	view →
CHOL	DFS	Median	All	0.221	0.723	<.001	41	view →
KICH	OS	Tertile	II,III,IV	0.470	0.936	.004	31	view →
READ	DFS	Median	II,III,IV	0.877	0.711	.006	30	view →
ACC	OS	Tertile	IV	0.262	0.747	.001	29	view →
BRCA	OS	Quartile	IV	0.908	0.368	.017	17	view →
MESO	DFS	Tertile	IV	0.160	0.580	.003	15	view →
SARC	OS	Quartile	All	0.426	0.622	.010	13	view →
SCLC	OS	Median	IV	0.201	0.772	.024	9	view →
HNSC	OS	Quartile	All	0.202	0.548	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

C1QBP–UVM (DFS)

Open the UVM breakdown →