C1QA

Across TCGA pan-cancer cohorts, C1QA mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C1QA data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C1QA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C1QA expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where C1QA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.768	1.000	.013	72	view →
PDAC	DFS	Median	All	0.301	0.503	<.001	53	view →
LUAD	OS	Tertile	III,IV	0.184	0.673	.010	24	view →
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	16	view →
UCEC	DFS	Tertile	All	0.786	0.983	.003	16	view →
GBM	OS	Tertile	All	0.724	0.930	.035	2	view →
HNSC	OS	Median	III,IV	0.894	0.805	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C1QA–COAD (DFS)

Open the COAD breakdown →