C1GALT1C1

Across TCGA pan-cancer cohorts, C1GALT1C1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C1GALT1C1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C1GALT1C1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C1GALT1C1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where C1GALT1C1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.875	0.697	.001	22	view →
LSCC	OS	Median	All	0.688	0.933	.002	22	view →
LUAD	OS	Median	II,III,IV	0.493	0.801	.012	18	view →
GBM	DFS	Quartile	All	0.190	0.531	.007	16	view →
UCEC	OS	Tertile	All	0.978	0.775	.008	8	view →
PDAC	OS	Quartile	III,IV	0.500	1.000	.040	3	view →
CCRCC	DFS	Median	III,IV	0.145	0.714	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C1GALT1C1–HNSC (DFS)

Open the HNSC breakdown →