C1GALT1C1

Across TCGA patient cohorts, C1GALT1C1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,168 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible C1GALT1C1-associated GO terms across cancer lineages are Negative regulation of IRE1-mediated unfolded protein response, Glycosylation, and Regulation of mitochondrial mRNA stability. Each is linked with C1GALT1C1 in more than 24 cancer types. Because this analysis shows association rather than direction, both C1GALT1C1-to-partner and partner-to-C1GALT1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of IRE1-mediated unfolded protein response grouped by C1GALT1C1-low versus C1GALT1C1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C1GALT1C1→partner) and Y-score (partner→C1GALT1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Negative regulation of IRE1-mediated unfolded protein response →	+0.112	+0.598	<.001	.002	3	25
ESCA	Glycosylation →	+0.048	+0.702	<.001	<.001	3	25
UVM	Regulation of mitochondrial mRNA stability →	+0.061	+0.973	<.001	<.001	3	24
ESCA	COPII-coated vesicle cargo loading →	+0.081	+0.529	<.001	<.001	2	25
UVM	Prenylation →	+0.084	+1.084	<.001	<.001	3	24
UVM	Protein quality control for misfolded or incompletely synthesized proteins →	+0.062	+1.167	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,168 associations by consensus.

Negative regulation of IRE1-mediated unfolded protein response by C1GALT1C1 expression — SCLC

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