C1GALT1C1

Across TCGA patient cohorts, C1GALT1C1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C1GALT1C1-associated genes across cancer lineages are eIF4E, PDK1_pS241, and 14-3-3_beta. Each is linked with C1GALT1C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1GALT1C1-to-partner and partner-to-C1GALT1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by C1GALT1C1-low versus C1GALT1C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1GALT1C1→partner) and Y-score (partner→C1GALT1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.200	+2.906	.008	.001	3	2
UCEC	PDK1_pS241 →	+0.132	+1.598	.032	.011	3	2
UCEC	14-3-3_beta →	-0.118	-3.558	.001	.002	3	1
UCEC	EGFR →	-0.128	-2.115	.026	.017	3	1
UCEC	A-Raf_pS299 →	-0.138	-3.807	.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.090	-1.990	.044	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by C1GALT1C1 expression — UCEC

Explore this box plot interactively →