C1GALT1

Across TCGA cell cohorts, C1GALT1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C1GALT1-associated genes across cancer lineages are GFRA4, OR14K1, and OR6K6. Each is linked with C1GALT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both C1GALT1-to-partner and partner-to-C1GALT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by C1GALT1-low versus C1GALT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C1GALT1→partner) and Y-score (partner→C1GALT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.021	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR14K1 →	+0.081	+4.437	<.001	.004	3	1
SKIN	OR6K6 →	+0.022	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GFRA4 by C1GALT1 expression — LARGE_INTESTINE

Explore this box plot interactively →