C19orf57

Across TCGA patient cohorts, C19orf57 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C19orf57-associated genes across cancer lineages are MAPK_pT202_Y204, Notch1, and Rictor_pT1135. Each is linked with C19orf57 in more than 1 cancer types. Because this analysis shows association rather than direction, both C19orf57-to-partner and partner-to-C19orf57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by C19orf57-low versus C19orf57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C19orf57→partner) and Y-score (partner→C19orf57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.429	-2.321	.031	.034	3	2
UCEC	Notch1 →	+0.268	+2.222	<.001	.011	3	2
UCEC	Rictor_pT1135 →	-0.124	-2.700	.004	.006	3	2
UCEC	EGFR_pY1068 →	-0.260	-2.222	.014	.011	3	1
UCEC	EGFR →	-0.265	-2.906	<.001	.001	3	1
UCEC	FoxM1 →	+0.224	+2.222	.041	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MAPK_pT202_Y204 by C19orf57 expression — UCEC

Explore this box plot interactively →